Clinical Studies on Lutein & Zeaxanthin
The Age-Related Eye Disease Study 2 (AREDS2), one of the largest and most comprehensive eye health studies conducted by the National Eye Institute, followed over 4,000 participants for 5 years. Results published in JAMA Ophthalmology demonstrated that daily supplementation with 10mg of lutein and 2mg of zeaxanthin reduced the risk of progression to advanced age-related macular degeneration by 25%. Vismax Revive contains double these clinically-proven dosages for even greater protection.
A 2017 meta-analysis published in Nutrients reviewed 20 randomized controlled trials and concluded that lutein and zeaxanthin supplementation significantly improved visual acuity, contrast sensitivity, and glare tolerance in both healthy individuals and those with early-stage AMD. The research showed measurable improvements in macular pigment optical density within 12 weeks of consistent supplementation, with continued benefits over longer periods.
Research on Bilberry Extract
Multiple European studies have validated bilberry's benefits for vision, particularly night vision and visual fatigue. A double-blind, placebo-controlled study published in the Journal of Nutrition and Health Sciences found that subjects taking 160mg of bilberry extract daily experienced a 45% improvement in night vision after 4 weeks compared to placebo. The anthocyanosides in bilberry were shown to increase rhodopsin regeneration and improve retinal adaptation to darkness.
Research from the University of Eastern Finland demonstrated that bilberry supplementation significantly improved microcirculation in the retina and reduced eye fatigue in individuals who spent more than 6 hours daily on digital devices. Participants reported 58% less eye strain and 63% reduction in dry eye symptoms after 8 weeks of supplementation with standardized bilberry extract.
Antioxidant Protection Studies
The original Age-Related Eye Disease Study (AREDS) established that high-dose antioxidant supplementation with vitamins C, E, zinc, and copper reduced the risk of developing advanced AMD by 25% over 5 years. Subsequent research has confirmed that this combination provides powerful protection against oxidative stress in the retina and lens, which are particularly vulnerable to free radical damage due to their high metabolic activity and light exposure.
A 2019 study in Investigative Ophthalmology & Visual Science demonstrated that comprehensive antioxidant supplementation including alpha-lipoic acid, grape seed extract, and the vitamin complex found in Vismax Revive reduced markers of oxidative stress in retinal cells by up to 72%. The researchers concluded that multi-antioxidant formulas provide synergistic protection superior to any single antioxidant alone.
Blue Light Protection Research
Recent studies on digital device usage and eye health have highlighted the importance of macular carotenoids in filtering harmful blue light. Research published in Nutrients (2021) showed that lutein and zeaxanthin supplementation increased macular pigment density, which directly correlates with improved blue light filtration. Participants with higher macular pigment levels reported 48% less digital eye strain and significantly better sleep quality.
A 2020 clinical trial examining the effects of lutein supplementation on computer users found that 20mg daily (the amount in Vismax Revive) improved visual performance, reduced glare disability, and enhanced photostress recovery after just 6 weeks. The study concluded that macular carotenoid supplementation should be considered essential for anyone with high screen time exposure to prevent long-term retinal damage from blue light.
